Methods and compositions to evaluate antibody treatment response

作者: Guillaume Cartron , Herve Watier , Phillippe Colombat

DOI:

关键词:

摘要: The present invention relates to methods and compositions evaluate or assess the response of a subject particular therapeutic treatment. More particularly, provides determine subjects, adapt treatment protocol subjects treated with antibodies. is based on determination FCGR3A genotype subject. can be used for patients malignancies, particularly lymphoma, suited select best responders and/or adjust condition low responders.

参考文章(40)
Robert E. Jordan, Fractionation of heparin ,(1982)
Toshihiko Yamada, Yoshiaki Hashimoto, Shuichi Saitoh, Keiichirou Yuasa, Mariko Moriguchi, Tetsurou Sekiguchi, Hitoshi Takagi, Ken Takehara, Ryuya Shimoda, Satoru Kakizaki, Hisashi Takayama, Takehiko Abe, Tastuhiko Matsumoto, Akira Kojima, Jirou Takezawa, Takeaki Nagamine, Masatomo Mori, Prediction of Effect of Interferon on Chronic Hepatitis C Digestive Diseases and Sciences. ,vol. 42, pp. 2270- 2276 ,(1997) , 10.1023/A:1018866717753
David G. Maloney, Antonio J. Grillo-López, Christine A. White, David Bodkin, Russell J. Schilder, James A. Neidhart, Nalini Janakiraman, Kenneth A. Foon, Tina-Marie Liles, Brian K. Dallaire, Ken Wey, Ivor Royston, Thomas Davis, Ronald Levy, IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma Blood. ,vol. 90, pp. 2188- 2195 ,(1997) , 10.1182/BLOOD.V90.6.2188
Robert P. Kimberly, Jeffrey C. Edberg, FC receptor polymorphism ,(1997)
Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, Susan F. Leitman, Lynn R. Goldin, Konrad Huppi, Stephen J. Chanock, Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations Blood. ,vol. 94, pp. 4220- 4232 ,(1999) , 10.1182/BLOOD.V94.12.4220
Robert L Shields, Angela K Namenuk, Kyu Hong, Y Gloria Meng, Julie Rae, John Briggs, Dong Xie, Jadine Lai, Andrew Stadlen, Betty Li, Judith A Fox, Leonard G Presta, None, High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR Journal of Biological Chemistry. ,vol. 276, pp. 6591- 6604 ,(2001) , 10.1074/JBC.M009483200
Xiao-Ming Jiang, Gow Arepally, Mortimer Poncz, Steven E. McKenzie, Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). Journal of Immunological Methods. ,vol. 199, pp. 55- 59 ,(1996) , 10.1016/S0022-1759(96)00164-0
B. A. Vance, P. M. Guyre, T. W. J. Huizinga, K. Wardwell, Binding of monomeric human IgG defines an expression polymorphism of Fc gamma RIII on large granular lymphocyte/natural killer cells. Journal of Immunology. ,vol. 151, pp. 6429- 6439 ,(1993)
Anthony Marfat, Substituted indazole derivatives ,(1997)