ChIP-BS-Sequencing in Cancer Epigenomics

摘要: DNA methylation and histone modifications are crucial epigenetic that involved in transcriptional regulatory network. Due to environmental cues, distortion epigenomic landscape—in modification—might be considered as a reason for aberrant gene expression cancer. A confounding puzzle cancer epigenetics is decipher whether significant mechanism between modification triggers tumorigenesis initiation progression. ChIP-BS-seq technique combines chromatin immunoprecipitation bisulfite conversion followed by high-throughput sequencing study genome-wide cross talk modification. In this chapter, we have explored background, technological advancement epigenomics research its future developments. We also summarized our latest findings on using cell lines.