Direct regulation of intestinal fate by Notch

摘要: The signals that maintain the proper balance between adult intestinal cell types are poorly understood. Loss-of-function studies have implicated Notch pathway in regulation of fate during development. However, it is unknown whether has a role maintaining different intestine and acts reversibly. To determine direct effect on development turnover, we used gain-of-function approach to activate Notch. Ectopic signaling progenitor cells leads bias against secretory fates, whereas ectopic activation embryonic foregut results reversible defects villus morphogenesis loss proliferative compartment. We conclude regulates by controlling absorptive types. In embryo, perturbs morphogenesis, possibly through effects stem or cells.