A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens
作者： Elisabeth Stockert , Elke Jäger , Yao-Tseng Chen , Matthew J. Scanlan , Ivan Gout
关键词:
摘要: Evidence is growing for both humoral and cellular immune recognition of human tumor antigens. Antibodies with specificity antigens initially recognized by cytotoxic T lymphocytes (CTLs), e.g., MAGE tyrosinase, have been detected in melanoma patient sera, CTLs NY-ESO-1, a cancer-testis (CT) antigen identified autologous antibody, recently identified. To establish screening system the response to autoimmunogenic antigens, an enzyme-linked immunosorbent assay (ELISA) was developed using recombinant MAGE-1, MAGE-3, SSX2, Melan-A, tyrosinase proteins. A survey sera from 234 cancer patients showed antibodies NY-ESO-1 19 patients, MAGE-1 3, MAGE-3 2, SSX2 1 patient. No reactivity these found 70 normal individuals. The frequency antibody 9.4% 12.5% ovarian patients. Comparison phenotype 62 stage IV that all NY-ESO-1+ had tumors, no NY-ESO-1− tumors antibody. As proportion melanomas expressing 20–40% only this would suggest high percentage develop NY-ESO-1.
rupress.org
core.ac.uk
jem.org
researchgate.net 参考文章(30)
DS Hoon, D. Yuzuki, Mike Hayashida, Donald L Morton, Melanoma patients immunized with melanoma cell vaccine induce antibody responses to recombinant MAGE-1 antigen. Journal of Immunology. ,vol. 154, pp. 730- 737 ,(1995)
Lloyd J. Old, Cancer Immunology: The Search for Specificity—G. H. A. Clowes Memorial Lecture Cancer Research. ,vol. 41, pp. 361- 375 ,(1981)
K Boller, O Janssen, H Schuldes, R R Tönjes, R Kurth, Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K. Journal of Virology. ,vol. 71, pp. 4581- 4588 ,(1997) , 10.1128/JVI.71.6.4581-4588.1997
Ingrid Schobert, Hans-Georg Rammensee, Michael Koslowski, Özlem Türeci, Gerhardt Seitz, Hans-Jörg Schild, Ugur Sahin, Michael Pfreundschuh, Frank Stenner, Holger Schmitt, The SSX-2 Gene, Which Is Involved in the t(X;18) Translocation of Synovial Sarcomas, Codes for the Human Tumor Antigen HOM-MEL-40 Cancer Research. ,vol. 56, pp. 4766- 4772 ,(1996)
Yao-Tseng Chen, Elisabeth Stockert, Yachi Chen, Pilar Garin-Chesa, Wolfgang J Rettig, Pierre van der Bruggen, Thierry Boon, Lloyd J Old, None, Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 1004- 1008 ,(1994) , 10.1073/PNAS.91.3.1004
B. S. Kwon, A. K. Haq, S. H. Pomerantz, R. Halaban, Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7473- 7477 ,(1987) , 10.1073/PNAS.84.21.7473
A. Knuth, B. Danowski, H. F. Oettgen, L. J. Old, T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin 2-dependent T-cell cultures Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 3511- 3515 ,(1984) , 10.1073/PNAS.81.11.3511
Elke Jäeger, Helga Bernhard, Pedro Romero, Mark Ringhoffer, Michael Arand, Julia Karbach, Christiane Ilsemann, Manfred Hagedorn, Alexander Knuth, Generation of cytotoxic T‐cell responses with synthetic melanoma‐associated peptides in vivo: Implications for tumor vaccines with melanoma‐associated antigens International Journal of Cancer. ,vol. 66, pp. 162- 169 ,(1996) , 10.1002/(SICI)1097-0215(19960410)66:2<162::AID-IJC4>3.0.CO;2-0
U. Sahin, O. Tureci, H. Schmitt, B. Cochlovius, T. Johannes, R. Schmits, F. Stenner, G. Luo, I. Schobert, M. Pfreundschuh, Human neoplasms elicit multiple specific immune responses in the autologous host. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 11810- 11813 ,(1995) , 10.1073/PNAS.92.25.11810
E J??ger, M Ringhoffer, M Arand, J Karbach, D J??ger, C llsemann, M Hagedorn, F Oesch, A Knuth, Cytolytic T cell reactivity against melanoma-associated differentiation antigens in peripheral blood of melanoma patients and healthy individuals Melanoma Research. ,vol. 6, pp. 419- 425 ,(1996) , 10.1097/00008390-199612000-00003