Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice.

摘要: This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated γ-Fe{sub 2}O{sub 3} NPs (10 mg kg{sup −1}) at organ, cellular and subcellular levels in healthy BALB/cJ mice parallel addresses effects NP injection on kidney function, blood pressure vascular contractility. Magnetic resonance imaging (MRI) transmission electron microscopy (TEM) showed accumulation liver within 1 h after intravenous infusion, accommodated by intracellular uptake endothelial Kupffer cells with subsequent renal cells, particularly cytoplasm proximal tubule, podocytes mesangial cells. The renofunctional were evaluated arterial acid–base status measurements glomerular filtration rate (GFR) instrumentation chronically indwelling catheters. Arterial pH was 7.46 ± 0.02 7.41 0.5 injections saline or NP, did not change over next 12 h. In addition, affect PCO{sub 2} [HCO{sub 3}{sup −}] either. Twenty-four 96 injections, GFR averaged 0.35 0.04 0.01 ml min{sup −1} g{sup −1}, respectively, values which statistically comparable controls (0.29 ±more » 0.33 0.1 ml{sup –1} 25 –1}). Mean (MAP) decreased 12–24 (111.1 11.5 vs 123.0 6.1 associated a contractility small mesenteric arteries revealed myography to characterize function. conclusion, our demonstrates that superparamagnetic iron oxide nanoparticles does function but temporarily decreases pressure. -- Highlights: ► PAA into mice. We examine physiological nanoparticle accumulation. No acid-base GFR. Acute hypotension vessels. demonstrate for medical purposes.« less