Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model

摘要: Misdirection of regenerating axons is one the factors that can explain poor results often found after nerve injury and repair. In this study, we quantified degree misdirection effect on recovery function different types repair in rat sciatic model; crush injury, direct coaptation, autograft Sequential tracing with retrograde labeling peroneal before 8 weeks was performed to quantify accuracy motor axon regeneration. Digital video analysis ankle motion used investigate function. addition, serial compound action potential recordings muscle morphometry were performed. our regeneration be limited; only 71% (±4.9%) motoneurons correctly directed 2 months 42% (±4.2%) 25% (±6.6%) Recovery incomplete all demonstrated a disturbed balance plantar dorsiflexion. The number from which had regenerated not significantly normal. myelinated increased distal site injury. major factor nerves innervate muscles. study as basis for developing new techniques may improve