LincRNAs and base modifications of p53 induced by arsenic methylation in workers.
作者： Weihua Wen , Lin Lu , Yuefeng He , Huirong Cheng , Fang He
DOI: 10.1016/J.CBI.2016.01.003
关键词:
摘要: Arsenic (As) metabolites could induce methylation changes of DNA and base modifications p53, which play role in the toxicity As. LincRNAs should a key regulatory p53 transcriptional response. There were 43 workers producing As trioxide, 36 who stopped exposure to trioxide about 85 days ago, 24 individuals as control group. Three species urine measured, primary secondary indexes, iAs%, MMA% DMA% calculated. RT-PCR was performed detect expression 7 exon 5, 6, 7, 8 p53. The concentrations urinary high workers. Compared group, significant for 5 found (P < 0.05), there came from two plants 0.05). exist various correlations between different expressions closely positive MMA/DMA MEG3/TUG1/HOTAIR/MALAT1 found, but negative correlation DMA/MALAT1 also be induced by As, MALAT1 unique roles epigenic changes. These findings suggest potentially widespread relative RNAs arsenic workers, may caused metabolism.
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