DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
作者： Elaine Gilmore , Nuala McCabe , Richard D. Kennedy , Eileen E. Parkes
DOI: 10.1155/2019/4325105
关键词:
摘要: Historically the development of anticancer treatments has been focused on their effect tumor cells alone. However, newer have shifted attention to targets immune cells, resulting in dramatic responses. The DNA repair deficiency microenvironment remains an area key interest. Moreover, established therapies such as damaging chemotherapy and PARP inhibitors further modify microenvironment. Here we describe pathways breast cancer activation innate deficiency, particular, STING (STimulator INterferon Genes) pathway. Breast tumors with are associated upregulation checkpoints including PD-L1 (Programmed Death Ligand-1) may represent a target population for single agent or combination immunotherapy treatment.
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