Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse.
作者： Elena De La Casa-Esperón , Carmen Sapienza , Fernando Pardo Manuel De Villena , Jan Michel Malette , Michelle Rosa
DOI: 10.1093/GENETICS/155.1.283
关键词:
摘要: Matings between (C57BL/6 x DDK)F(1) females and C57BL/6 males result in a significant excess of offspring inheriting maternal DDK alleles the central region mouse chromosome 11 due to meiotic drive at second division. We have shown previously that locus subject selection is vicinity D11Mit66, marker closely linked Om controls preimplantation embryo-lethal phenotype known as "DDK syndrome." also observation this system depends upon genotype sire. Here we show are heterozygous retain define 0.32-cM candidate interval for Responder system. In addition, analysis inheritance among F(1) intercrosses indicates effect sire determined by sperm or Om.
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