Testicular seminoma with human chorionic gonadotropin production

摘要: Testicular seminoma with elevated serum human chorionic gonadotropin level (hCG-positive seminoma) is regarded as more malignant than marker-negative seminoma, although its prognosis still unclear. To clarify the potential of hCG production, levels beta subunit (beta-hCG) and lactic acid dehydrogenase (LDH) were examined in 35 40 patients, respectively, immunohistochemical expression beta-hCG 45 tumors. The elevation LDH correlated to invasive status, metastatic status poor outcome, while that only status. Immunohistochemical was observed syncytiotrophoblastic giant cells 11 tumors a few mononuclear 36 Expression not associated malignancy potential, except where inversely These results suggest most seminomas produce slight amount hCG; an indicates presence mainly reflects increase tumor volume but cellular potential; level, rather hCG, useful prognostic indicator for patients seminoma.