Increased Platelet and Erythrocyte Arginase Activity in Chronic Obstructive Pulmonary Disease Associated With Tobacco or Wood Smoke Exposure

摘要: Background Chronic obstructive pulmonary disease (COPD) is an inflammatory that characterized by a progressive and irreversible decline in lung function caused primarily chronic exposure to tobacco wood smoke. It linked oxidative stress up-regulation of airway arginases also associated with alterations platelets erythrocytes. In the present study, arginase activity was studied erythrocytes 2 groups COPD patients: 31 ex-smokers 27 patients who had been exposed A total 15 healthy controls were included. Methods Plasma, platelets, obtained from blood samples. Levels biomarkers, carbonyls malondialdehyde, measured plasma, quantified Results both patients, increase biomarkers found. Platelet 2-fold higher than control group. erythrocytes, increased 1.7-fold over only smoke-induced Discussion Conclusions These results suggest participates alteration nitric oxide metabolism there may be some differences between smoke- COPD.