CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer

摘要: Background The repetitive antigen stimulation during chronic infection often leads to the accumulation of CD8+CD57+ T cells. These cells express high levels interferon-γ, granzyme B and perforin with elevated cytolytic effect, are considered as most potent for combating chronical viral infection. status in non-small cell lung cancer (NSCLC) has not been well defined. Methods We used flow cytometry undertook a systemic approach examine frequency, immunophenotyping functional properties peripheral blood, tumor tissue corresponding normal tissue, draining lymph nodes, patients NSCLC. Results CD57+ expressed programmed death-1 (PD-1) all tested compartments were predominantly CD8+ blood displayed terminally differentiated phenotype defined by loss CD27 CD28 while expressing KLRG1. exhibited enhanced cytotoxic potencies impaired proliferative capability. Unlike significant proportion primary tumors CD28. lacked activity. activity these was also impaired. tissues shared similarities their counterparts rather than tumors. vast majority nodes positive unable produce B, but preserved. an inferior response PD-1 blockade compared CD8+CD57- counterparts. Interleukin (IL)-15 preferentially restored effector function Additionally, IL-15 able restore blood. Conclusions Our data indicate that failure immune system fight progression could be result T-cell maturation into fully within microenvironment. Boosting might promote tumor-reactive preserving