Incomplete Differentiation of Antigen-Specific CD8 T Cells in Tumor-Draining Lymph Nodes

摘要: CD8 T cells lacking effector activity have been recovered from lymphoid organs of mice and patients with progressing tumors. We explored the basis for lack in tumor-bearing by evaluating Ag presentation cell function over course tumor outgrowth. Early after injection, cross-presentation bone marrow-derived APC was necessary activation, inducing proliferation differentiation into IFN-γ-producing, cytolytic effectors. At later stages outgrowth, metastasized to draining lymph nodes. Both cross- direct occurred, but induced either modality incomplete (proliferation without cytokine production). within tumor-infiltrated nodes differentiated appropriately if presented activated, exogenous dendritic cells. Thus, activated develop through late-stage mice, rather than suppression previously