Monodisperse Micro-Oil Droplets Stabilized by Polymerizable Phospholipid Coatings as Potential Drug Carriers.

摘要: There is a critical need to formulate stable micron-sized oil droplets as hydrophobic drug carriers for efficient encapsulation, long-term storage, and sustained release. Microfluidic methods were developed maximize the stability of micron-sized, oil-in-water (o/w) emulsions potential use in delivery, using doxorubicin-loaded triacetin model formulation. Initial experiments examined multiple flow conditions dispersed (oil) continuous (liposome aqueous) phases microfluidic device establish parameters that influenced droplet size. These data fit mathematical from literature indicate sizes formed are controlled by ratio rates height channel, rather than orifice Next, we investigated effects o/w emulsion production on droplets. The produced flow-focusing techniques was found be much greater (5 h vs 1 h) mechanical agitation (vortexing). increased attributed uniform size lipid distribution generated flow-focusing. In contrast, vortexed populations consisted wide resulted higher prevalence Ostwald ripening. Finally, shell polymerization comparing encapsulated photopolymerizable diacetylene those with nonpolymerizable shell. Shell significantly enhance against dissolution flow-focused but did not affect Overall, results these show promising technique generating tunable, stable, monodisperse emulsions, applications delivery formulations.