Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain.
作者： Valerio Magnaghi , Luca Franco Castelnovo , Alessandro Faroni , Erica Cavalli , Lucia Caffino
DOI: 10.1155/2014/368678
关键词:
摘要: Neuropathic pain arises as a direct consequence of lesion or disease affecting the peripheral somatosensory system. It may be associated with allodynia and increased sensitivity. Few studies correlated neuropathic nerve morphology myelin proteins expression. Our aim was to test if is related degeneration, speculating whether modulation GABA-B receptors promote regeneration decrease pain. We used partial sciatic ligation- (PSL-) induced model. The biochemical, morphological, behavioural outcomes were analysed following ligands treatments. Simultaneous 7-days coadministration baclofen (10 mg/kg) CGP56433 (3 alters tactile hypersensitivity. Concomitantly, specific changes morphology, structure, (P0 PMP22) expression observed. Nerve macrophage recruitment decreased step coordination improved. PSL-induced in nociception correlate altered protein Peripheral synergic effects, via receptor activation, likely ameliorate
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Yoshinori Otsuki, Kiyoto Kanbara, Mitsuo Kinoshita, Masahito Watanabe, Katsuya Watanabe, Tetsuji Yanagawa, Shigenori Tamura, Expression and distribution of GABAergic system in rat knee joint synovial membrane. Histology and Histopathology. ,vol. 24, pp. 1009- 1019 ,(2009) , 10.14670/HH-24.1009
Charles R. Gerfen, Ron McKay, Jacqueline N. Crawley, Current protocols in neuroscience John Wiley. ,(1997)
Valerio Magnaghi, Patrizia Procacci, Ada Maria Tata, Chapter 15: Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration. International Review of Neurobiology. ,vol. 87, pp. 295- 315 ,(2009) , 10.1016/S0074-7742(09)87015-3
Barbara Grimpe, Jerry Silver, Chapter 23 The extracellular matrix in axon regeneration Progress in Brain Research. ,vol. 137, pp. 333- 349 ,(2002) , 10.1016/S0079-6123(02)37025-0
Alessandro Faroni, Luca Franco Castelnovo, Patrizia Procacci, Lucia Caffino, Fabio Fumagalli, Simona Melfi, Giovanna Gambarotta, Bernhard Bettler, Lawrence Wrabetz, Valerio Magnaghi, Deletion of GABA-B receptor in Schwann cells regulates remak bundles and small nociceptive C-fibers. Glia. ,vol. 62, pp. 548- 565 ,(2014) , 10.1002/GLIA.22625
Biao B. Sun, Shing Yan Chiu, N-type calcium channels and their regulation by GABAB receptors in axons of neonatal rat optic nerve. The Journal of Neuroscience. ,vol. 19, pp. 5185- 5194 ,(1999) , 10.1523/JNEUROSCI.19-13-05185.1999
Gerhard H. Fromm, The pharmacology of trigeminal neuralgia. Clinical Neuropharmacology. ,vol. 12, pp. 185- 194 ,(1989) , 10.1097/00002826-198906000-00003
Vladimir P Zagorodnyuk, Giuseppe D'Antona, Simon J.H Brookes, Marcello Costa, Functional GABAB receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings. Autonomic Neuroscience: Basic and Clinical. ,vol. 102, pp. 20- 29 ,(2002) , 10.1016/S1566-0702(02)00183-2
Wilfred A. Nix, H.C. Hopf, Electrical stimulation of regenerating nerve and its effect on motor recovery Brain Research. ,vol. 272, pp. 21- 25 ,(1983) , 10.1016/0006-8993(83)90360-8
Jian-Guo Cui, Björn A Meyerson, Alf Sollevi, Bengt Linderoth, Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABAB and adenosine receptor activation Neuroscience Letters. ,vol. 247, pp. 183- 186 ,(1998) , 10.1016/S0304-3940(98)00324-3