GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination.

摘要: GABA-B receptors are important for Schwann cell (SC) commitment to a non-myelinating phenotype during development. However, the P0-GABA-B1fl/fl conditional knockout mice, lacking GABA-B1 receptor specifically in SCs, also presented axon modifications, suggesting SC non-autonomous effects through neuronal compartment. In this vitro study, we evaluated whether specific deletion of SCs may induce autonomous or cross-changes sensory dorsal root ganglia (DRG) neurons. To end, performed an biomolecular and transcriptomic analysis DRG neuron primary cultures from mice. We found that cells mice exhibited proliferative, migratory myelinating alterations. Moreover, changes novel molecules involved peripheral neuron–SC interaction.