Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes

作者: Shaoxian Chen , Juli Liu , Xiaoying Liu , Yongheng Fu , Mengzhen Zhang

DOI: 10.1016/J.JEP.2011.05.011

关键词:

摘要: … Results of this study suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in both the in vitro and in vivo models through activating PI3K/Akt signaling …

参考文章(31)
Giora Z. Feuerstein, Apoptosis--new opportunities for novel therapeutics for heart diseases. Cardiovascular Drugs and Therapy. ,vol. 15, pp. 547- 551 ,(2001) , 10.1023/A:1013775906652
Guido Kroemer, John C. Reed, Mitochondrial control of cell death Nature Medicine. ,vol. 6, pp. 513- 519 ,(2000) , 10.1038/74994
Naoufal Zamzami, Guido Kroemer, THE MITOCHONDRION IN APOPTOSIS: HOW PANDORA'S BOX OPENS Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 67- 71 ,(2001) , 10.1038/35048073
Paul Chan, Brian Tomlinson, G Neil Thomas, Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease. Acta Pharmacologica Sinica. ,vol. 23, pp. 1157- 1162 ,(2002)
Antti Saraste, Kari Pulkki, Markku Kallajoki, Kenth Henriksen, Martti Parvinen, Liisa-Maria Voipio-Pulkki, Apoptosis in Human Acute Myocardial Infarction Circulation. ,vol. 95, pp. 320- 323 ,(1997) , 10.1161/01.CIR.95.2.320
Carolyn J. Mullonkal, Luis H. Toledo-Pereyra, Akt in Ischemia and Reperfusion Journal of Investigative Surgery. ,vol. 20, pp. 195- 203 ,(2007) , 10.1080/08941930701366471
Linda S Steelman, Kristin M Stadelman, William H Chappell, Stefan Horn, Jörg Bäsecke, Melchiorre Cervello, Ferdinando Nicoletti, Massimo Libra, Franca Stivala, Alberto M Martelli, James A McCubrey, Akt as a therapeutic target in cancer. Expert Opinion on Therapeutic Targets. ,vol. 12, pp. 1139- 1165 ,(2008) , 10.1517/14728222.12.9.1139
Wei-Xing Guo, Quentin N. Pye, Kelly S. Williamson, Charles A. Stewart, Kenneth L. Hensley, Yashige Kotake, Robert A. Floyd, Robert H. Broyles, Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free Radical Biology and Medicine. ,vol. 39, pp. 641- 650 ,(2005) , 10.1016/J.FREERADBIOMED.2005.04.013
Shinji Negoro, Hidemasa Oh, Eiroh Tone, Keita Kunisada, Yasushi Fujio, Kenneth Walsh, Tadamitsu Kishimoto, Keiko Yamauchi-Takihara, Glycoprotein 130 Regulates Cardiac Myocyte Survival in Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation and Bcl-xL/Caspase-3 Interaction Circulation. ,vol. 103, pp. 555- 561 ,(2001) , 10.1161/01.CIR.103.4.555