Integrative repair of the meniscus: lessons from in vitro studies.

摘要: Current therapies for meniscal injury seek to preserve and repair damaged tissue since loss of is associated with degenerative changes in the joint, ultimately leading osteoarthritis (OA). After a tear, difficulty integrating juxtaposed surfaces continues be an obstacle. In order determine local factors that are necessary successful repair, previous studies have developed vitro model systems allow both biological quantitative biomechanical measures meniscus repair. Many shown importance individual metabolism, but there complex interplay among variety influence healing, including inflammatory cytokines, growth factors, mechanical loading, zonal differences cell properties. particular, upregulation cytokines following joint appears significant catabolic influences on metabolic activity must overcome promote presence such as interleukin-1 (IL-1) or tumor necrosis factor alpha (TNF-α), intrinsic significantly inhibited. While anabolic transforming factor-β1 (TGF-β1), enhance they cannot completely IL-1-mediated inhibition The mechanisms by which these mediators their interactions other microenvironment, remain determined. Future address during healing