Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction

摘要: Right ventricular (RV) dysfunction is the most important determinant of survival in patients with pulmonary hypertension (PH). The manifestations RV not only include changes global systolic function but also abnormalities pattern contraction and synchrony. effects PH on right ventricle have been mainly studied arterial (PAH). However, demographic shift towards an aging population, heart failure preserved ejection fraction (HFpEF) has become etiology recent years. There are significant differences mechanics, adaptation between PAH HFpEF (with or without PH), which related to different patterns remodeling dysfunction. Due unique features chamber, its connection main artery circulation, understanding mechanics clinical significance mandatory for both entities. In this review, we describe pressure overloaded ventricle. We review mechanical components dyssynchrony, followed by insights via analysis pressure-volume loop, energetics novel blood flow patterns, such as vortex imaging. conduct in-depth comparison prevalence characteristics PAH, summarize key outcome studies. Finally, provide a perspective needed expected future work field mechanics.