Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use

摘要: Antihistamines are a mainstay treatment for allergic rhinitis; however, many older agents cause adverse events, including sedation and central nervous system (CNS) impairment. Research has shown sedating effects of antihistamines on driving; currently, no known study examined whether cellular phone usage while driving further compounds impairment in individuals administered antihistamines. The aim this was to examine endpoint. In randomized, double-blind, placebo-controlled, three-way crossover study, healthy volunteers received fexofenadine HCl 120 mg, hydroxyzine 30 mg placebo. Brake reaction time (BRT) used performance across four conditions: only; completing simple calculations; complex conversing phone. Subjective assessments were also conducted. with without fexofenadine-treated subjects did not differ significantly from placebo any condition. contrast, hydroxyzine-treated more sedated had slower BRTs, suggesting hazard recognition brake application, compared the groups all conditions. Importantly, operation an additive factor, increasing BRTs volunteers. Fexofenadine impair CNS function involved divided attention task operation.