RAPID DECREASE IN LYMPHOCYTE ADHERENCE TO HIGH ENDOTHELIAL VENULES IN LYMPH-NODES DEPRIVED OF AFFERENT LYMPHATIC VESSELS
作者： Hans R. Hendriks , Adrian M. Duijvestijn , Georg Kraal
关键词:
摘要: Occlusion of the afferent lymph flow to node (LN) results in both flattening endothelium high endothelial venules (HEV) and a severe decrease numbers lymphocytes transit across walls flattened HEV. In present study we have used vitro lymphocyte-binding assay investigate ability HEV rat LN bind at various time points after occlusion flow. addition specificity T B lymphocyte adherence such operated was studied. In normal LN, adhered virtually all using binding assay. However, 1 2 weeks operation bound only 50–60% by 3–6 20–30%. The total these had also diminished 10% control value operation. Morphometric analysis showed that this not due reduction area available for cells, but strong per unit endothelium. spite adhering T/B cell ratio did change. show is rapid event, probably loss determinants involved lymphocytes. clearly precedes suggesting height cells secondary importance adherence.
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