Calcium transients in single adrenal chromaffin cells detected with aequorin
作者： Peter H. Cobbold , Timothy R. Cheek , K.S. Roy Cuthbertson , Robert D. Burgoyne
DOI: 10.1016/0014-5793(87)81271-1
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摘要: Abstract The effect of 55 mM K + and nicotine on intracellular free calcium was monitored in bovine adrenal chromaffin cells microinjected with aequorin. In contrast to results quin 2, which suggested that stimulation resulted sustained rises calcium, aequorin measurements showed a transient (60–90 s) elevation calcium. peak duration the elicited by were dose-dependent. concentration (10 μM) giving maximal secretory response gave rise up 1 μM. only releases 30% catecholamine released 10 μM generated indistinguishable from due nicotine. These support idea nicotinic agonists generate an alternative second messenger addition
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