Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

摘要: Parturition is a complex mammalian physiological process whose fundamental determinants have remained elusive. The increasing incidence of human preterm birth, leading cause infant mortality, highlights the importance further understanding mechanisms regulating timing birth. initiated in most nonprimate mammals, including mice, through decrease circulating progesterone caused by elevated prostaglandins. In humans, other higher primates, and guinea pigs, no consistent occurs before onset labor. divergence endocrine control labor initiation between mammals compared with great apes pigs gives rise to question: how could mechanism for not requiring withdrawal evolve? Here, we genetically modulate prostaglandin signaling determine role catabolism We find spontaneous absence progester...