Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations.

摘要: TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a ubiquitous environmental contaminant and known endocrine disruptor. Since humans animals are most sensitive to toxicant exposure during development, we previously developed mouse model of in utero order examine the impact this on adult reproductive function. Our initial toxicant-exposure study revealed dose-dependent reduction uterine sensitivity progesterone; however, did not explore establishment or maintenance pregnancy. Thus, current study, examined pregnancy outcomes C57BL/6 mice with history developmental exposure. Herein demonstrate reduced fertility an increased incidence premature birth (PTB) F1 exposed as well three subsequent generations. Finally, our studies that exhibit inflammation which further negatively impacted gestation length all generations examined.