Helicobacter pylori and acetylsalicylic acid synergistically accelerate apoptosis via Fas antigen pathway in rabbit gastric epithelial cells
作者： Kazuhiro Watanabe , Satoshi Hoshiya , Kengo Tokunaga , Akifumi Tanaka , Hidehiro Watanabe
关键词:
摘要: The mechanism for gastric epithelial cellular apoptosis by both H. pylori and NSAIDs remains unknown. Normal cells, collected from rabbit stomach, were cultured with viable and/or an acetylsalicylic acid 24 hr as in vitro model of cell injury. Fas antigen expression rate the cells was measured using a FACScan. In group E, which inoculation followed treatment NSAID, significantly higher than observed after either or NSAID alone. Despite fact that drug alone did not increase vs control cells. results suggest induce injury via pathway synergistic manner this effect is particularly strong when follows infection.
springer.com
sci-hub.se 参考文章(27)
Jeanmarie Houghton, Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Digestive Diseases and Sciences. ,vol. 44, pp. 465- 478 ,(1999) , 10.1023/A:1026628601284
Murali K.R. Tummuru, Martin J. Blaser, Timothy L. Cover, Ping Cao, Stuart A. Thompson, Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. Journal of Biological Chemistry. ,vol. 269, pp. 10566- 10573 ,(1994) , 10.1016/S0021-9258(17)34097-8
David Y. Graham, Martin D. Lidsky, Annalee M. Cox, Doyle J. Evans, Dolores G. Evans, Lesley Alpert, Peter D. Klein, Sandra L. Sessoms, Patrice A. Michaletz, Zahid A. Saeed, Long-term nonsteroidal antiinflammatory drug use and Helicobacter pylori infection Gastroenterology. ,vol. 100, pp. 1653- 1657 ,(1991) , 10.1016/0016-5085(91)90665-8
S Wagner, W Beil, J Westermann, RP Logan, CT Bock, C Trautwein, JS Bleck, MP Manns, Regulation of gastric epithelial cell growth by Helicobacter pylori: Offdence for a major role of apoptosis Gastroenterology. ,vol. 113, pp. 1836- 1847 ,(1997) , 10.1016/S0016-5085(97)70003-9
S Yonehara, A Ishii, M Yonehara, A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor Journal of Experimental Medicine. ,vol. 169, pp. 1747- 1756 ,(1989) , 10.1084/JEM.169.5.1747
L E French, M Hahne, I Viard, G Radlgruber, R Zanone, K Becker, C Müller, J Tschopp, Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. Journal of Cell Biology. ,vol. 133, pp. 335- 343 ,(1996) , 10.1083/JCB.133.2.335
M. R Tramer, Aspirin, like all other drugs, is a poison. BMJ. ,vol. 321, pp. 1170- 1171 ,(2000) , 10.1136/BMJ.321.7270.1170
Fusao Ueda, Takashi Kyoi, Kiyotaka Mimura, Kiyoshi Kimura, Masao Yamamoto, Intercellular communication in cultured rabbit gastric epithelial cells. Japanese Journal of Pharmacology. ,vol. 57, pp. 321- 328 ,(1991) , 10.1254/JJP.57.321
J Rudi, D Kuck, S Strand, A von Herbay, S M Mariani, P H Krammer, P R Galle, W Stremmel, Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. Journal of Clinical Investigation. ,vol. 102, pp. 1506- 1514 ,(1998) , 10.1172/JCI2808
RJ Hopkins, LS Girardi, EA Turney, Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review Gastroenterology. ,vol. 110, pp. 1244- 1252 ,(1996) , 10.1053/GAST.1996.V110.PM8613015