Association between polymorphisms of DNA repair genes and survival of advanced NSCLC patients treated with platinum-based chemotherapy

摘要: Abstract Background Single nucleotide polymorphism (SNP) in DNA repair genes can be used to explain the differences survival of platinum-treated non-small cell lung cancer (NSCLC) patients regardless their performance status. To define role gene SNPs NSCLC patients, we investigated association between and 12 different 9 genes. Methods 340 were treated with platinum-based chemotherapy. Polymorphisms detected by real time PCR TaqMan probe, using genomic extracted from peripheral blood samples. Multivariate logistic or Cox regression analyses adjust for possible confounding variables. Results The median overall was 15 months it significantly longer harboring ERCC1 118 C/T T/T allele: 18 as compared 13.8 C/C allele ( P  = 0.014). Subgroup analysis revealed that associated increased elderly  = 0.018), male  = 0.022), squamous carcinoma  = 0.003), smoker  = 0.076) those non-gemcitabine/cisplatin carboplatin (non-GP/GC) regimen  = 0.023). XRCC3C/C better Both CCNH-V270A XPD 751 A/A showed a significant subgroup  = 0.047  = 0.034 respectively). Conclusion Present data indicates might provide prognostic predictive marker chemotherapy, mainly subgroup, male, carcinoma, non-GP/GC regimen.