ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.
作者： R Metzger , C G Leichman , K D Danenberg , P V Danenberg , H J Lenz
DOI: 10.1200/JCO.1998.16.1.309
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摘要: PURPOSEWe have previously shown that relative thymidylate synthase (TS) mRNA levels in primary gastric adenocarcinomas treated with fluorouracil (5-FU) and cisplatin are inversely associated response survival. This is a presumed function of TS as target for 5-FU activity. We now test the hypotheses level excision repair cross-complementing (ERCC1) gene survival an independent efficacy.PATIENTS AND METHODSPatients had intact, untreated, adenocarcinoma cancer were evaluated eligibility on preoperative infusion-5-FU protocol. cDNA, derived from tumors before chemotherapy, was used to determine ERCC1 levels, expressed ratio polymerase chain reaction (PCR) product beta-actin gene.RESULTSThe median 38 cancers (33 assessable response) 5.8 x 10(-3) (range, 1.8 t...
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