Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.
作者： André G. Sousa , Lívia Selvatici , José E. Krieger , Alexandre C. Pereira
关键词:
摘要: Type 2 diabetes and coronary artery disease (CAD) are conditions that cause a substantial public health burden. Since both often coexist in the same individual, it has been hypothesized they have common effector. Insulin hyperglycemia assumed to play critical roles this scenario. In recent years, many genetic risk factors for CAD discovered, mainly through genome-wide association studies. Genetic aspects of diabetes, diabetic macrovascular complications, intersections leading effector hypothesis. However, only few could be identified modulate conditions. Polymorphisms TCF7L2 near CDKN2A/B genes seem great importance regard since appear conditions, not necessarily related insulinism, or hyperglycemia, development. Other issues hypothesis, such as problems phenotype heterogeneity, also interest. Recent studies contributed better understanding complex genetics complications. Much effort is still needed clarify associations cardiovascular disease. At present, there little evidence support other than insulin between these
diabeticstudies.org参考文章(55)
Masoud Amini, Mohsen Janghorbani, Diabetes and Impaired Glucose Regulation in First-Degree Relatives of Patients with Type 2 Diabetes in Isfahan, Iran: Prevalence and Risk Factors The review of diabetic studies : RDS. ,vol. 4, pp. 169- 176 ,(2007) , 10.1900/RDS.2007.4.169
Carl D. Langefeld, Lynne E. Wagenknecht, Thomas C. Register, Donald W. Bowden, David Herrington, Subhashish Agarwal, Fang-Chi Hsu, Jeff D. Williamson, Amanda Julie Cox, Joseph A. Maldjian, J. Jeffrey Carr, Maggie C.-Y. Ng, Christina E. Hugenschimdt, Barry I. Freedman, Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. The review of diabetic studies : RDS. ,vol. 7, pp. 188- 201 ,(2010) , 10.1900/RDS.2010.7.188
Diabetes Control and Complications Trial, None, Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. The New England Journal of Medicine. ,vol. 353, pp. 2643- 2653 ,(2005) , 10.1056/NEJMOA052187
NJ Morrish, S-L Wang, LK Stevens, JH Fuller, H Keen, WHO Multinational Study Group, Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia. ,vol. 44, ,(2001) , 10.1007/PL00002934
Takashi Kadowaki, Toshimasa Yamauchi, Adiponectin and Adiponectin Receptors Endocrine Reviews. ,vol. 26, pp. 439- 451 ,(2005) , 10.1210/ER.2005-0005
Robert Roberts, David R. Cox, David A. Hinds, Len A. Pennacchio, Anne Tybjaerg-Hansen, Aaron R. Folsom, Eric Boerwinklle, Helen H. Hobbs, Jonathan C. Cohen, Ruth McPherson, Alexander Pertsemlidis, Nihan Kavaslar, Alexandre Stewart, A common allele on chromosome 9 associated with coronary heart disease Obstetrical & Gynecological Survey. ,vol. 62, pp. 584- 585 ,(2007) , 10.1097/01.OGX.0000279314.45442.BB
Sara E. Pinney, Rebecca A. Simmons, Epigenetic mechanisms in the development of type 2 diabetes Trends in Endocrinology and Metabolism. ,vol. 21, pp. 223- 229 ,(2010) , 10.1016/J.TEM.2009.10.002
Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul IW de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen, Kristin Ardlie, Kristina Bengtsson Boström, Richard N Bergman, Lori L Bonnycastle, Knut Borch-Johnsen, Noël P Burtt, Hong Chen, Peter S Chines, Mark J Daly, Parimal Deodhar, Chia-Jen Ding, Alex SF Doney, William L Duren, Katherine S Elliott, Michael R Erdos, Timothy M Frayling, Rachel M Freathy, Lauren Gianniny, Harald Grallert, Niels Grarup, Christopher J Groves, Candace Guiducci, Torben Hansen, Christian Herder, Graham A Hitman, Thomas E Hughes, Bo Isomaa, Anne U Jackson, Torben Jørgensen, Augustine Kong, Kari Kubalanza, Finny G Kuruvilla, Johanna Kuusisto, Claudia Langenberg, Hana Lango, Torsten Lauritzen, Yun Li, Cecilia M Lindgren, Valeriya Lyssenko, Amanda F Marvelle, Christa Meisinger, Kristian Midthjell, Karen L Mohlke, Mario A Morken, Andrew D Morris, Narisu Narisu, Peter Nilsson, Katharine R Owen, Colin NA Palmer, Felicity Payne, John RB Perry, Elin Pettersen, Carl Platou, Inga Prokopenko, Lu Qi, Li Qin, Nigel W Rayner, Matthew Rees, Jeffrey J Roix, Anelli Sandbaek, Beverley Shields, Marketa Sjögren, Valgerdur Steinthorsdottir, Heather M Stringham, Amy J Swift, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Nicholas J Timpson, Tiinamaija Tuomi, Jaakko Tuomilehto, Mark Walker, Richard M Watanabe, Michael N Weedon, Cristen J Willer, Wellcome Trust Case Control Consortium, Thomas Illig, Kristian Hveem, Frank B Hu, Markku Laakso, Kari Stefansson, Oluf Pedersen, Nicholas J Wareham, Inês Barroso, Andrew T Hattersley, Francis S Collins, Leif Groop, Mark I McCarthy, Michael Boehnke, David Altshuler, None, Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nature Genetics. ,vol. 40, pp. 638- 645 ,(2008) , 10.1038/NG.120
Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti, Judy H Cho, Alan E Guttmacher, Augustine Kong, Leonid Kruglyak, Elaine Mardis, Charles N Rotimi, Montgomery Slatkin, David Valle, Alice S Whittemore, Michael Boehnke, Andrew G Clark, Evan E Eichler, Greg Gibson, Jonathan L Haines, Trudy FC Mackay, Steven A McCarroll, Peter M Visscher, None, Finding the missing heritability of complex diseases. Nature. ,vol. 461, pp. 747- 753 ,(2009) , 10.1038/NATURE08494
J. B. Meigs, L. A. Cupples, P. W. Wilson, Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes. ,vol. 49, pp. 2201- 2207 ,(2000) , 10.2337/DIABETES.49.12.2201