Age-adjusted validation of the most stringent criteria for active surveillance in low-risk prostate cancer patients†

摘要: BACKGROUND: The authors tested the performance of currently used clinical criteria reported in populations studied by van den Bergh et al and Carter for selection patients with prostate cancer (PCa) active surveillance (AS) according to age. METHODS: Data were analyzed from 893 who underwent radical prostatectomy (RP). The investigated rates unfavorable PCa at RP (extracapsular extension, seminal vesicle or lymph node invasion, Gleason score 7-10) fulfilled AS age tertiles (ages ≤63 years, 63.1 69 >69 years). Area under plasma concentration time curve (AUC) analyses predicting PCa. Then, stratified cutoff 70 years. Multivariate test role PCa. RESULTS: The rate characteristics was between 24% 27.8%. In population, after 41% compared 23.2% 24.1% previous years respectively). 41.2% 17.3% 18.6% When 70-year used, identified 17.9% 23.6% aged (all P < .001). AUC revealed significantly lower older patients. multivariate analyses, adjustment prostate-specific antigen, volume, number cores, represented an independent predictor PCa. CONCLUSIONS: The performed better <70 concluded that current results should be taken into account when deciding whether offer low-risk Cancer 2012;. © 2011 American Society.