GPIHBP1 autoantibody syndrome during interferon β1a treatment
作者： Jun Eguchi , Kazuya Miyashita , Isamu Fukamachi , Katsuyuki Nakajima , Masami Murakami
DOI: 10.1016/J.JACL.2018.10.004
关键词:
摘要: Background Autoantibodies against glycosylphosphatidylinositol-anchored high-density lipoprotein–binding protein 1 (GPIHBP1) cause chylomicronemia by blocking the ability of GPIHBP1 to bind lipoprotein lipase (LPL) and transport enzyme its site action in capillary lumen. Objective A patient with multiple sclerosis developed during interferon (IFN) β1a therapy. The resolved when IFN therapy was discontinued. Here, we sought determine whether drug-induced caused autoantibodies. Methods We tested plasma samples collected after for autoantibodies (by western blotting enzyme-linked immunosorbent assays). also patient's blocked binding LPL on GPIHBP1-expressing cells. Results During therapy, contained autoantibodies, those GPIHBP1's LPL. Thus, because autoantibody syndrome. Consistent that diagnosis, levels were very low. After stopped, triglyceride returned normal, undetectable. Conclusion appearance chylomicronemia. disappeared fell within normal range.
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