Interferon-gamma induces HLA-DR expression by thyroid epithelium.

摘要: We recently showed that human thyroid epithelial cells, which are normally negative for HLA-DR molecules, express in autoimmunity. Furthermore, induction of on normal cells can be achieved by culture with plant lectins. have now found recombinant interferon-gamma (IFN-gamma) induces expression molecules cultured whereas Namalva IFN-alpha, IFN-beta or interleukin-2 (IL-2) do not. All three IFN, but not IL-2, enhanced cell HLA-A,B,C expression. The results strongly implicate T (which the source IFN-gamma) aberrant DR is proposed to a central feature immunopathological processes leading