Significance and Regulation of the Expression of MHC Class II Molecules on Autoimmune and Neoplastic Thyroid Cells

摘要: Publisher Summary MHC class II molecules consist of several isotypes, which are encoded by a highly polymorphic gene cluster, and expressed as codominant alleles. responsible for the presentation exogeneous antigens to helper T cells. The expression is normally restricted cells immune system; nonimmune express only in abnormal situations, such viral infection, autoimmune diseases, malignancies. chapter describes Class on malignant thyroid crucial event process antigen induction or inhibition an response. On thyrocytes expression, lead self-antigens, perpetuate autoimmunity. self-thyroid tumor-antigens, direct response toward these destroy them. discusses molecular basis regulation expression: chromatin structure DNA methylation, post-transcriptional regulation, polymorphism promoter region, promoters structure, transcription factors. basic mechanisms share similar features with those regulating their cells: similar, factors utilized, transactivator (CIITA) plays key role "master regulator", However, additional employed MHS like shorter half-life values.