Comparison of heartworm extract-induced shock and endotoxin-induced shock in dogs by determination of serum tumor necrosis factor concentrations.
作者： Katsuya Kitoh , Hiroko Katoh , Hitoshi Kitagawa , Yoshihide Sasaki
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摘要: Objective—To compare the mechanisms of heartworm (HW) extract-induced shock and endotoxininduced in dogs by determination serum tumor necrosis factor (TNF) concentrations. Animals—11 mixed-breed (7 without 4 with HW infections). Procedure—Eight were treated 2 ml extract IV, 3 given endotoxin (Escherichia colili popolysaccharide [LPS]) at 40 or 400 μg/kg body weight, IV. Changes clinical hematologic findings TNF concentrations examined from before treatment to 120 minutes after 180 LPS. Tumor concentration was determined cytotoxic assay, using WEHI-164 murine sarcoma cells, plasma extract, endotoxin-specific chromogenic test. Results—Eight developed 16 treatment. Rectal temperature did not change du...
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