Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3-Substituted 2-(Trifluoromethyl)piperidines
作者： Sarah Rioton , Aurélie Orliac , Zeina Antoun , Roselyne Bidault , Domingo Gomez Pardo
DOI: 10.1021/ACS.ORGLETT.5B01084
关键词:
摘要: 3-Substituted 2-(trifluoromethyl)piperidines B were synthesized by ring expansion of (trifluoromethyl)prolinols A, which obtained from l-proline via an aziridinium intermediate C. The opening the (trifluoromethyl)aziridinium different nucleophiles is regio- and diastereoselective.
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