Endocannabinoid Signaling in Hypothalamic-Pituitary-Adrenocortical Axis Recovery Following Stress: Effects of Indirect Agonists and Comparison of Male and Female Mice

摘要: Studies in male rodents have shown that stress-induced increases circulating corticosterone are increased by both CB1 receptor (CB1R) antagonist treatment and genetic deletion. The purposes of the current study were to determine whether female mice respond same manner as males, indirect CB1R agonists accelerate return baseline. In agreement with earlier studies, null rimonabant-treated had significantly 30 min following end a restraint episode compared wild type vehicle-treated, respectively. Females treated rimonabant higher vehicle. However, concentrations not different between females at recovery, although 90 recovery. Female exhibited greater serum binding capacity for than type. monoacylglycerol lipase inhibitor, JZL184, attenuated offset male, recovery Male JZL184 120 even absence restraint. no effect on mice. fatty acid amide hydrolase URB597, did affect responses or female, These data suggest 2-arachidonoylglycerol is primary endocannabinoid involved regulation HPA axis from stress. support role endocannabinoid-CB1R signaling response stress life-long loss undergo compensatory changes minimize impact corticosterone.