Enteropathogenic viruses: Triggers for exacerbation in IBD? A prospective cohort study using real-time quantitative polymerase chain reaction

摘要: Background: While the role of bacteria as an etiological factor triggering relapse in inflammatory bowel disease (IBD) has been studied extensively, little is known enteric viruses. We aimed to prospectively study prevalence and risk factors for common enteropathogenic viruses IBD patients relation activity. Methods: IBD visiting outpatient clinic Maastricht University Medical Center were included a prospective cohort with follow-up 1 year. Every 3 months during relapses, fecal samples, demographic, clinical data collected activity was scored. A sample from at baseline (Crohn's [CD] n = 170, ulcerative colitis [UC] 116) additional subgroup changing (CD 57, UC 31) analyzed presence rotavirus, norovirus GI GII, human astrovirus, adenovirus using quantitative polymerase chain reaction (qPCR). Results: Overall viral pathogen detection, defined by detection least one viruses, 5.2% differed neither between CD (6.5%) or (3.4%) (P 0.20), nor active (4.7%) remission (5.5%) 0.79). Within no association found overall 0.39). Using multivariate logistic regression, age, gender, subtype, activity, medication, season sampling not associated detection. Conclusions: Enteropathogenic are frequently observed consecutive trigger daily practice. (Inflamm Bowel Dis 2012;)