The novel SNPs of leptin gene and their associations with growth traits in Chinese Nanjiang Yellow goat
作者： Cen Wang , Hao Zhang , Lili Niu , Jiazhong Guo , Xianbo Jia
DOI: 10.1016/J.GENE.2015.06.073
关键词:
摘要: Abstract The leptin (LEP) gene encodes a protein that greatly affects the regulation of body weight, energy balance, and food intake in mammals. objective present work was to identify genetic variants caprine LEP 411 individuals from five Chinese goat breeds. Six novel single nucleotide polymorphisms (SNPs) (g.117 T > C, g.1642G > A, g.2883G > A, g.3053 T > C, g.3190G > A, g.3314 T > C) were detected using DNA sequencing. A chi-squared (χ2) test showed all SNPs Hardy–Weinberg equilibrium studied population (P > 0.05). common haplotypes identified populations, with frequencies ranging 0.083 0.244. r2 linkage disequilibrium plot indicated only cultured breeds (NJ JY). Statistical analysis revealed six associated growth traits. GG genotype at g.1642G > A g.3190G > A loci higher birth weight (2.38 ± 0.03, 2.43 ± 0.05) 2 months age (10.59 ± 0.16, 10.71 ± 0.26) than A-bearing genotypes (AA or GA, P
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