Leptin gene polymorphisms and their phenotypic associations.
作者： T. van der Lende , M.F.W. te Pas , R.F. Veerkamp , S.C. Liefers
DOI: 10.1016/S0083-6729(05)71013-X
关键词:
摘要: In an era of rapidly increasing prevalence human obesity and associated health problems, leptin gene polymorphisms have drawn much attention in biomedical research. Leptin furthermore from animal scientists for their possible roles economically important production reproduction traits. Of the reported exonic, intronic, promoter regions gene, 16 been included association studies humans, 19 cattle, 6 (all exonic or intronic) pigs. associations found with overweight (early-onset) obesity, non-insulin-dependent diabetes mellitus, prostate cancer, non-Hodgkin's lymphoma. feed intake, milk yield traits, carcass reproduction-related pigs average daily gain, traits (backfat/leanness), performance Many were only a limited number studies, phenotypes studied varied largely given polymorphism between studies. Therefore, many these need to be confirmed future before firm conclusions can drawn.
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