Implications of False Negative and False Positive Diagnosis in Lymph Node Staging of NSCLC by Means of 18F-FDG PET/CT

作者: Shaolei Li , Qingfeng Zheng , Yuanyuan Ma , Yuzhao Wang , Yuan Feng

DOI: 10.1371/JOURNAL.PONE.0078552

关键词:

摘要: Background Integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is widely performed in hilar and mediastinal lymph node (HMLN) staging of non-small cell lung cancer (NSCLC). However, the diagnostic efficiency PET/CT remains controversial. This retrospective study to evaluate accuracy characteristics false negatives positives improve specificity sensitivity.

参考文章(21)
Kazuo Kubota, Koji Murakami, Tomio Inoue, Harumi Itoh, Tsuneo Saga, Susumu Shiomi, Jun Hatazawa, Additional value of FDG-PET to contrast enhanced-computed tomography (CT) for the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Japanese multicenter clinical study Annals of Nuclear Medicine. ,vol. 25, pp. 777- 786 ,(2011) , 10.1007/S12149-011-0529-4
Robert James Cerfolio, Ayesha S. Bryant, Buddhiwardhan Ohja, Alfred A. Bartolucci, The maximum standardized uptake values on positron emission tomography of a non-small cell lung cancer predict stage, recurrence, and survival. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 130, pp. 151- 159 ,(2005) , 10.1016/J.JTCVS.2004.11.007
Andrea R.G. Sheel, James McShane, Michael P. Poullis, Survival of Patients With or Without Symptoms Undergoing Potentially Curative Resections for Primary Lung Cancer The Annals of Thoracic Surgery. ,vol. 95, pp. 276- 284 ,(2013) , 10.1016/J.ATHORACSUR.2012.09.051
Sung Shine Shim, Kyung Soo Lee, Byung-Tae Kim, Myung Jin Chung, Eun Jung Lee, Joungho Han, Joon Young Choi, O Jung Kwon, Young Mog Shim, Seonwoo Kim, Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. Radiology. ,vol. 236, pp. 1011- 1019 ,(2005) , 10.1148/RADIOL.2363041310
Barbara Fischer, Ulrik Lassen, Jann Mortensen, Søren Larsen, Annika Loft, Anne Bertelsen, Jesper Ravn, Paul Clementsen, Asbjørn Høgholm, Klaus Larsen, Torben Rasmussen, Susanne Keiding, Asger Dirksen, Oke Gerke, Birgit Skov, Ida Steffensen, Hanne Hansen, Peter Vilmann, Grete Jacobsen, Vibeke Backer, Niels Maltbæk, Jesper Pedersen, Henrik Madsen, Henrik Nielsen, Liselotte Højgaard, None, Preoperative Staging of Lung Cancer with Combined PET–CT The New England Journal of Medicine. ,vol. 361, pp. 32- 39 ,(2009) , 10.1056/NEJMOA0900043
Man Hu, Anqin Han, Ligang Xing, Wenfeng Yang, Zheng Fu, Chengsuo Huang, Pinliang Zhang, Li Kong, Jinming Yu, Value of dual-time-point FDG PET/CT for mediastinal nodal staging in non-small-cell lung cancer patients with lung comorbidity. Clinical Nuclear Medicine. ,vol. 36, pp. 429- 433 ,(2011) , 10.1097/RLU.0B013E3182173810
Kimihiro Shimizu, Junji Yoshida, Kanji Nagai, Mitsuyo Nishimura, Genichiro Ishii, Yasuo Morishita, Yutaka Nishiwaki, Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer The Journal of Thoracic and Cardiovascular Surgery. ,vol. 130, pp. 160- 165 ,(2005) , 10.1016/J.JTCVS.2004.11.021
T BILFINGER, Surgical viewpoints for the definitive treatment of lung cancer. Respiratory Care Clinics of North America. ,vol. 9, pp. 141- 162 ,(2003) , 10.1016/S1078-5337(02)00086-2
Hiroko Suzuki, John Robert Minarcik, Keratoconus Complicated by Acute Corneal Hydrops New England Journal of Medicine. ,vol. 361, pp. e32- ,(2009) , 10.1056/NEJMICM0805963
Ayesha S. Bryant, Robert J. Cerfolio, Katrin M. Klemm, Buddhiwardhan Ojha, Maximum standard uptake value of mediastinal lymph nodes on integrated FDG-PET-CT predicts pathology in patients with non-small cell lung cancer. The Annals of Thoracic Surgery. ,vol. 82, pp. 417- 423 ,(2006) , 10.1016/J.ATHORACSUR.2005.12.047