Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects.

摘要: In this study the rate of lipolysis (fatty acid and glycerol release into blood) has been quantified in both normal weight obese volunteers after 15 87 h fasting. each study, basal subsequent response to epinephrine infusion (0.015 microgram X kg-1 min-1) were determined. The appearance (Ra) free fatty acids (FFA) by [1-13C]palmitate D-5-glycerol, respectively. Substrate flux rates per unit body fat mass lean calculated from total water measurements using H2(18)O dilution. volunteers, Ra FFA rose markedly with fasting, whereas increases more modest subjects. However, mobilization fat, relation mass, was higher subjects than values similar groups There an increased lipolytic fasting groups. This sensitivity may have resulted enhancement acid-triglyceride substrate cycling that occurred