Modeling the WHO-EPI Vaccine Supply Chain in Low and Middle Income Countries

摘要: The enormous economic impact of diseases has drawn global attention and controlling through a vaccination program is one the highest priorities in healthcare decision making. However, successful implementation programs must also consider distribution network design logistical feasibility. In this research we address issue via three broad contributions. First, develop generic mathematical programming model WHO-EPI vaccine low middle countries, adapt to answer actual logistics questions such as assessing feasibility new introductions, changing design, vial size an existing using West African country Niger illustrate this. Second, explore integrating decisions with immunization policies by developing framework for linking supply chain disease propagation model. used assess measles interventions order help policy makers decide on appropriate policy. Third, significant challenge increasing clinic visit rate, especially areas limited health care resources high-risk populations. To do application passive cold devices delivery at remote sites. Such mobile are easy deploy locations that off electricity grid or have unstable energy supply, they can be support outreach vaccinations families rural areas. We computational evaluate cost effectiveness different device designs real world networks. conduct sensitivity analysis determine which most robust respect fluctuations performance.