Intraocular co-grafts of fetal dorsal raphe nucleus and suprachiasmatic nucleus.

作者: Shuichi Ueda , Yasuhiro Matsumoto , Efrain C. Azmitia , Mitsuhiro Kawata

DOI: 10.1016/0006-8993(93)91738-E

关键词:

摘要: Serotonergic neurons in the fetal dorsal raphe nucleus were grafted together with anterior hypothalamic tissue including suprachiasmatic (SCN) to eye chamber of adult rats. After 6 weeks transplantation, double grafts immunocytochemically examined using antisera against serotonin, arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP). The contained a large number serotonin-immunoreactive fibers, but only few AVP-immunoreactive fibers VIP-immunoreactive fibers. On other hand, numerous AVP- found SCN graft. Outgrowing from densely distributed In SCN, however, detected. results demonstrate that isolated can be innervated by serotonergic grafts, innervation pattern these was quite different normal rat. present indicate has an inhibitory influence on growth

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