Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors

作者: G. Baggio , S. Donazzan , D. Monti , D. Mari , S. Martini

DOI: 10.1096/FASEBJ.12.6.433

关键词:

摘要: In this study we assessed whether widely accepted risk factors for atherosclerotic vascular diseases such as lipoprotein(a) [Lp(a)], a cholesterol-rich lipoprotein under strict genetical control, and other lipid parameters change with age. The variations of blood levels the pathophysiological role Lp(a) in old people, particularly oldest old, are unknown. Accordingly, measured well total, LDL, HDL cholesterol (CT), triglycerides (TG) sera from 75 healthy centenarians, 114 randomly selected subjects 65 years, 73 elderly 30 people. results showed that serum did not vary by age group, including centenarians. Remarkably, one-quarter centenarians had high even though they never suffered atherosclerosis-related diseases. At variance young aged also plasma concentrations proinflamm...

参考文章(28)
D Mari, PM Mannucci, R Coppola, B Bottasso, KA Bauer, RD Rosenberg, Hypercoagulability in centenarians : the paradox of successful aging Blood. ,vol. 85, pp. 3144- 3149 ,(1995) , 10.1182/BLOOD.V85.11.3144.BLOODJOURNAL85113144
P Sansoni, A Cossarizza, V Brianti, F Fagnoni, G Snelli, D Monti, A Marcato, G Passeri, C Ortolani, E Forti, Lymphocyte Subsets and Natural Killer Cell Activity in Healthy Old People and Centenarians Blood. ,vol. 82, pp. 2767- 2773 ,(1993) , 10.1182/BLOOD.V82.9.2767.2767
Michael R. Rose, Evolutionary biology of aging ,(1990)
G R Warnick, J Benderson, J J Albers, Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry. ,vol. 28, pp. 1379- 1388 ,(1982) , 10.1093/CLINCHEM/28.6.1379
Charles C Allain, Lucy S Poon, Cicely S G Chan, W Richmond, Paul C Fu, Enzymatic determination of total serum cholesterol. Clinical Chemistry. ,vol. 20, pp. 470- 475 ,(1974) , 10.1093/CLINCHEM/20.4.470
G Utermann, The mysteries of lipoprotein(a) Science. ,vol. 246, pp. 904- 910 ,(1989) , 10.1126/SCIENCE.2530631
Yoshiyuki Miyashita, Shigeto Morimoto, Keisuke Fukuo, Shunji Imanaka, Eio Koh, Michio Tamatani, Toshio Ogihara, Participation of Decreased Serum CholesteryI Ester Transfer Activity, Independent of Increased Serum Lipoprotein(a), in Angina Pectoris in Normolipemic Elderly Subjects Gerontology. ,vol. 38, pp. 258- 267 ,(1992) , 10.1159/000213338
William B. Ershler, Interleukin-6: a cytokine for gerontologists. Journal of the American Geriatrics Society. ,vol. 41, pp. 176- 181 ,(1993) , 10.1111/J.1532-5415.1993.TB02054.X
S. Maeda, A. Abe, M. Seishima, K. Makino, A. Noma, M. Kawade, Transient changes of serum lipoprotein(a) as an acute phase protein Atherosclerosis. ,vol. 78, pp. 145- 150 ,(1989) , 10.1016/0021-9150(89)90218-9