Optimal interaction of respiratory and thermal regulation at rest and during exercise: Role of a serotonin-gated spinoparabrachial thermoafferent pathway

摘要: Recent evidence indicates that the lateral parabrachial nucleus (LPBN) in dorsolateral pons is pivotal mediating feedback control of inspiratory drive by central chemoreceptor input and feedforward body temperature cutaneous thermoreceptor input. The latter subject to descending serotonergic inhibition which gates transmission ascending thermoafferent information from spinal dorsal horn LPBN. Here, a model proposed suggests LPBN may be important balancing respiratory thermal homeostasis, two conflicting goals are heightened environmental heat/cold stress or exercise where effects thermolysis become prominent. This optimization respiratory-thermoregulatory interaction supported host recent studies demonstrate animals with serotonin (5-HT) dysfunction at horn--due 5-HT antagonism, genetic defects cord injury--all display similar abnormalities consistent hyperactivity spinoparabrachial (and pain) pathway.