The use of bio-metal concentrations correlated with clinical prognostic factors to assess human breast tissues

摘要: Worldwide, breast cancer is the most frequently diagnosed in women and leading cause of death among women. The concentrations bio-metals are crucial for homeostasis human health being shown to have significantly different when comparing tissue normal tissue. This first study that correlates findings differences levels certain elements between individual tumours, clinical prognostic factors such as oestrogen receptor (ER) status, lymph node tumour size, grade, menopause epidermal growth factor 2 relapsed status survival status. Micro probe synchrotron radiation X-ray fluorescence techniques been used determine localization relative Zn, Cu, Fe Ca 128 formalin-fixed paraffin-embedded invasive ductal (IDC) samples surrounding statistical analysis reveals a significant increase Ca, Fe, Cu Zn by 85%, 20%, 23% 117%, respectively, IDC compared Our shows increased expressions all associated with ER positive cancers also indicates imbalance iron concentration (deficiency) should be viewed an important risk aggressive features cancer. Characterisation difference regions will help selecting treatment novel agents chelate or zinc. Copyright © 2013 John Wiley & Sons, Ltd.