Sex differences in skin carotenoid deposition and acute UVB‐induced skin damage in SKH‐1 hairless mice after consumption of tangerine tomatoes

摘要: Scope UVB exposure, a major factor in the development of skin cancer, has differential sex effects. Tomato product consumption reduces intensity UVB-induced erythema humans, but mechanisms are unknown. Methods and results Four-week-old SKH-1 hairless mice (40 females, 40 males) were divided into two feeding groups (control or with 10% tangerine tomatoes naturally rich UV-absorbing phytoene phytofluene) UV exposure (with without UV). After 10 weeks feeding, group was exposed to single dose sacrificed 48 h later. Blood dorsal samples taken for carotenoid analysis. Dorsal harvested assess effects on deposition, inflammation (skinfold thickness, myeloperoxidase levels), DNA damage (cyclobutane pyrimidine dimers, p53). Females had significantly higher levels both blood carotenoids relative males. reduced females not attenuated acute UV-induced increases CPD sexes, activity percent p53 positive epidermal cells Conclusion Tangerine mediate via through