Self-assembled nanogel of pluronic-conjugated heparin as a versatile drug nanocarrier

摘要: Heparin has not been used as a macromolecule to prepare nanocarriers for drug delivery, even though it advantageous structural features, such negatively charged structure and presence of specific binding domains proteins. In this study, nanogel Pluronic-conjugated heparin was prepared by direct dissolution develop versatile nanocarrier composed heparin. The aqueous solution the heparin-Pluronic (HP) conjugate, exhibited higher stability than micelles smaller hydrodynamic size 100 nm. encapsulation test demonstrated that HP encapsulates efficiently both hydrophobic small molecules release profile indomethacin (IMC) almost zero-order without burst due heparin, which appears be comparing polymeric micelles. Circular dichroism (CD) gel electrophoresis monoclonal antibodies (3D8 scFv) encapsulated into had maintained. Overall, self-assembled may promising range drugs in delivery applications.