Peganum harmala can minimize Escherichia coli infection in poultry, but long-term feeding may induce side effects.

摘要: ABSTRACT Peganum harmala seed extracts have been frequently reported to possess antibacterial potential through in vitro studies, but vivo studies acquired less attention. The present study was therefore designed investigate its efficacy on the course of colibacillosis and effects long-term feeding selected parameters general health chickens. Two experiments were conducted this regard. Experiment 1 (a pilot study) performed determine dose a field strain Escherichia coli (O1:K1) required induce clinical symptoms 4- 15-d-old specific-pathogen-free A successful induction colibacillosis, terms signs, mortality, pathological lesions addition reisolation pathogen observed by inoculating chicks with 4.3 log10 6.4 cfu E. coli, respectively, intraperitoneal injection. Using these doses experiment 2 (main consisting single 3 parts performed. Parts B generated information regarding extract against infection chickens applying different treatment schemes, whereas continuous assessed part C. Whereas no protective effect could be recorded young chickens, significant differences (P