Predictors of longitudinal outcomes after unstable response to acute-phase cognitive therapy for major depressive disorder

摘要: After patients with major depressive disorder (MDD) respond to acute-phase cognitive therapy (CT), continuation-phase treatments may be applied improve long-term outcomes. We clarified which CT responders experience remission, recovery, relapse, and recurrence by testing baseline demographic, clinical, personality variables. The sample of at higher risk relapse (N = 241) was randomized 8 months CT, double-blinded fluoxetine, or pill placebo, followed 24 (Jarrett & Thase, 2010). Patients lower positive emotionality behavioral activation the end showed increased for relapse/recurrence MDD. In addition, activation, as well residual depression (including emotional, cognitive, social facets), decreased probability remission (≥6 continuous weeks minimal absent symptoms) after CT. Finally, greater depression, younger age earlier MDD onset, recovery (≥35 Moderator analyses did not reveal differential prediction across continuation phase treatment arms. These results help clinicians gauge prognoses need among who