Early-Morning Hyperglycemia in Diabetic Individuals Treated with Continuous Subcutaneous Insulin Infusion
作者： M. E. Geffner , H. J. Frank , S. A. Kaplan , B. M. Lippe , S. R. Levin
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摘要: Significant early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of five key counterregulatory hormones (CRH) throughout night for total 10 patient-nights four such patients. No abnormalities patterns glucagon, cortisol, growth hormone, epinephrine, or norepinephrine secretion observed. Stepping up daytime basal infusionrate six affected patients before bedtime by 37.0 ± 7.5% and maintaining increased until breakfast significantly blunted this without causing significant early nighttime hypoglycemia. Plasma glucose concentrations averaged 106.8 13.0 mg/dl after increase overnight rate as compared with 269.8 39.1 single over 24 h ( P
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Guenther Boden, J. Stuart Soeldner, A sensitive double antibody radioimmunoassay for human growth hormone (HGH): levels of serum HGH following rapid tolbutamide infusion. Diabetologia. ,vol. 3, pp. 413- 421 ,(1967) , 10.1007/BF01228076
P. N. PRINZ, J. HALTER, C. BENEDETTI, M. RASKIND, Circadian Variation of Plasma Catecholamines in Young and Old Men: Relation to Rapid Eye Movement and Slow Wave Sleep The Journal of Clinical Endocrinology and Metabolism. ,vol. 49, pp. 300- 304 ,(1979) , 10.1210/JCEM-49-2-300
M. I. Schmidt, A. Hadji-Georgopoulos, M. Rendell, S. MargoliS, D. Kowarski, A. A. Kowarski, Fasting Hyperglycemia and Associated Free Insulin and Cortisol Changes in “Somogyi-Like” Patients Diabetes Care. ,vol. 2, pp. 457- 464 ,(1979) , 10.2337/DIACARE.2.6.457
R. H. Unger, The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell Diabetes. ,vol. 25, pp. 136- 151 ,(1976) , 10.2337/DIAB.25.2.136
LUIZ DE LACERDA, AVINOAM KOWARSKI, CLAUDE J. MIGEON, Integrated Concentration and Diurnal Variation of Plasma Cortisol1 The Journal of Clinical Endocrinology and Metabolism. ,vol. 36, pp. 227- 238 ,(1973) , 10.1210/JCEM-36-2-227
William L. Clarke, Lorraine Thomas, Julio V. Santiago, Clinical evaluation and preliminary studies on the use of an artificial pancreatic beta cell in juvenile diabetes mellitus The Journal of Pediatrics. ,vol. 91, pp. 590- 596 ,(1977) , 10.1016/S0022-3476(77)80508-8
J. S. Skyler, D. E. Seigler, M. L. Reeves, Optimizing Pumped Insulin Delivery Diabetes Care. ,vol. 5, pp. 135- 139 ,(1982) , 10.2337/DIACARE.5.2.135
John Gerich, Philip Cryer, Robert Rizza, Hormonal mechanisms in acute glucose counterregulation: The relative roles of glucagon, epinephrine, norepinephrine, growth hormone, and cortisol Metabolism-clinical and Experimental. ,vol. 29, pp. 1164- 1175 ,(1980) , 10.1016/0026-0495(80)90026-8
Massimo Menchini, Franco Meschi, Roberto Lambiase, Maria Puzzovio, Maria Jose Del Guercio, Giuseppe Chiumello, C-Peptide response to arginine stimulation in diabetic children The Journal of Pediatrics. ,vol. 96, pp. 362- 366 ,(1980) , 10.1016/S0022-3476(80)80673-1
Y. Takahashi, D. M. Kipnis, W. H. Daughaday, Growth hormone secretion during sleep Journal of Clinical Investigation. ,vol. 47, pp. 2079- 2090 ,(1968) , 10.1172/JCI105893